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碱性螺旋-环-螺旋

名词解释题

2022-01-11 14:06

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碱性螺旋-环-螺旋存在于一些参与多细胞生物发育期间控制基因表达的真核生物调节蛋白之中。这些蛋白都有一个50个氨基酸残基的保守区。它对该蛋白质与DNA结合及本身二聚化都很重要。这与DNA结合的螺旋-转角-螺旋结构模序不同，这个区域能形成由一个可变长度肽环连系的两个短的双α螺旋。这个螺旋-环-螺旋和另一个蛋白的这种模序相结合以形成二聚体。与DNA的结合则是由一串富含碱性氨基酸残基的肽链介导的。这个肽链直接与螺旋-环-螺旋相连。

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