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Ph染色体

名词解释题
2021-09-02 00:01
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正确答案

90%以上的慢粒患者及部分急淋白血病患者其在血细胞中出现Ph染色体,该染色体是9号染色体长臂远端与22号染色体短臂易位形成t(9;22)(q34;q11)。这样9号染色体长臂上的细胞原癌基因ABL易位至22号染色体的断裂集中区(BCR)形成BCR-ABL融合基因,由此产生一种新的mRNA,翻译出异常的蛋白质P。现在认为P对引起慢粒白血病有直接联系。


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