可引起红细胞渗透脆性增高的溶血性贫血是（） -题库考试答案搜索网

可引起红细胞渗透脆性增高的溶血性贫血是（）

单选题

2021-12-25 12:24

A、α海洋性贫血
B、β海洋性贫血
C、镰型细胞贫血
D、阵发性睡眠性血红蛋白尿
E、遗传性球形细胞增多症

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正确答案

E

试题解析

红细胞的渗透脆性与红细胞的面积／体积的比值有关，海洋性贫血是珠蛋白肽链数量异常导致的HA，镰形细胞贫血是珠蛋白肽链质量（结构）异常导致的HA，均属于遗传性血红蛋白病，可排除；D和E均为红细胞膜异常导致的HA，阵发性睡眠性血红蛋白尿(PNH)为获得性红细胞膜异常，对激活补体敏感导致红细胞破坏的血管内溶血；遗传性球形细胞增多症是红细胞膜骨架蛋白异常，该病患者球形红细胞面积／体积的比值缩小，脆性增加，更容易发生溶血。

标签：血液科皮肤科住院医师内科急诊科住院医师

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