A、the advertising center moved to the west states.
B、Madison Avenue agencies lost their leading positions in advertising.
C、the agencies of the industry no longer lies in the Madison Avenue.
D、the creatives get more and more working pressures.
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试题解析
第一段第二句提到“…the most dramatic shift is in the center of power of the entire industry”,其中the most dramatic shift对应题干中的The biggest change。该段接下来指出“麦迪逊大街上的广告公司不再处于广告业的创新前沿”,与选项B所表达意思相符。