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细菌的耐药性 (resistance of bacteria)

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2022-05-22 21:00
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又称抗药性,一般是指细菌与药物多次接触后,对药物的敏感性下降甚至消失,致使药物对耐药菌的疗效降低或无效。细菌对抗生素(包括抗菌药物)的耐药机制主要有四种:
(1)使抗生素分解或失去活性;
(2)使抗菌药物作用的靶点发生改变;
(3)细菌细胞膜渗透性的改变或其它特性的改变使抗菌药物无法进入细胞内;
(4)细菌产生药泵将进入细胞的抗菌素泵出细胞。

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