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肾病综合征典型症状大量蛋白尿的主要产生原因是()

单选题
2021-12-30 00:29
A、肾小管重新吸收能力降低
B、血浆胶体渗透压下降
C、肾小球毛细血管基底膜的滤过作用受损
D、肝脏合成蛋白的能力增加
E、肾血流量增加
查看答案

正确答案
C

试题解析
肾病综合征患者的大量蛋白尿是由于肾小球毛细血管基底膜的滤过作用受损所致。由于滤过膜的分子屏障,特别是电荷屏障受损,通透性显著增加而引起大量蛋白尿,与肾小管再吸收功能降低无关。血浆白蛋白的大量丢失引起低白蛋白血症导致血浆渗透压降低,引起水肿。机体为补偿低白蛋白血症,才导致肝脏合成白蛋白能力的增加。肾病综合征患者摄入高蛋白饮食可增加尿蛋白的漏出,在正常肾,高蛋白饮食不会引起蛋白尿。肾病综合征时肾脏血流量一般无变化。

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